# Life Sciences Grade 12 P2 NSC November 2021 QP (Eng)

> Grade 12 Life Sciences Paper 2 question paper from the NSC November Exam 2021 (English), 17 pages. Read online or download the free PDF.

- Page: https://www.hlayiso.com/library/life-sciences-p2-nov-2021-eng/e82d515d-e011-458c-b9c1-91eab007ea8c
- Updated: 2026-09-27
- Subject: Life Sciences
- Grade: Grade 12
- Document type: Question paper
- Year: 2021
- Exam period: NSC November Exam
- Paper: 2
- Curriculum: CAPS
- Pages: 17

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## About this document

Life Sciences · Grade 12 · NSC November Exam · 2021. Question paper, 17 pages. Read online or download the PDF.

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                                  GRAAD 12

                                  NATIONAL
                             SENIOR CERTIFICATE

                                     GRADE 12

                                LIFE SCIENCES P2

                                 NOVEMBER 2021

MARKS: 150

TIME: 2½ hours

                       This question paper consists of 17 pages.

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Life Sciences/P2                             2                             DBE/November 2021
                                            NSC

INSTRUCTIONS AND INFORMATION

Read the following instructions carefully before answering the questions.

1.        Answer ALL the questions.

2.        Write ALL the answers in the ANSWER BOOK.

3.        Start the answers to EACH question at the top of a NEW page.

4.        Number the answers correctly according to the numbering system used in this
          question paper.

5.        Present your answers according to the instructions of each question.

6.        Do ALL drawings in pencil and label them in blue or black ink.

7.        Draw diagrams, tables or flow charts only when asked to do so.

8.        The diagrams in this question paper are NOT necessarily drawn to scale.

9.        Do NOT use graph paper.

10.       You must use a non-programmable calculator, protractor and a compass,
          where necessary.

11.       Write neatly and legibly.

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Life Sciences/P2                              3                             DBE/November 2021
                                             NSC

SECTION A

QUESTION 1

1.1      Various options are provided as possible answers to the following questions.
         Choose the answer and write only the letter (A to D) next to the question
         numbers (1.1.1 to 1.1.9) in the ANSWER BOOK, e.g. 1.1.10 D.

          1.1.1       DNA and RNA are examples of …

                      A   amino acids.
                      B   enzymes.
                      C   nucleic acids.
                      D   proteins.

          1.1.2       Which ONE of the following is a product of meiosis?

                      A   Muscle cell
                      B   Ovary
                      C   Nerve cell
                      D   Ovum

          1.1.3       An individual is heterozygous for a harmful recessive allele but is
                      unaffected by it.

                      Which ONE of the following best represents the genetic
                      composition of this individual?

                      A   Two dominant normal alleles
                      B   One harmful recessive allele and one harmful dominant
                          allele
                      C   One harmful recessive allele and one normal dominant allele
                      D   One harmful dominant allele and one normal recessive allele

          1.1.4       A person has the genotype IAi for blood type.

                      What is this person's blood group?

                      A   A
                      B   B
                      C   O
                      D   AB

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Life Sciences/P2                               4                           DBE/November 2021
                                              NSC

          1.1.5       In a car accident, the biological father of a girl and three other men
                      were killed. The men could not be identified due to their injuries.
                      DNA profiling was used to identify the girl's father.

                      The diagram below shows the DNA profiles of the girl, her mother
                      and the four men.

                                                              Man
                              Girl   Mother
                                                  1       2         3        4

                      Which ONE of the men is most likely to have been the father of the
                      girl?

                     A    4
                     B    3
                     C    2
                     D    1

          1.1.6       A DNA template strand codes for the amino acid serine with any of
                      the following base triplets:

                                     AGA AGG AGT TCA TCG AGC

                      The anticodon that codes for the amino acid serine is …

                      A   AGT.
                      B   UGA.
                      C   TCG.
                      D   UCG.

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Life Sciences/P2                               5                        DBE/November 2021
                                              NSC

          1.1.7       The diagram below represents two phases of meiosis.

                                      A                            B

                      Which ONE of the following represents the correct sequence of
                      phases between phase A and phase B?

                      A   Anaphase I, Metaphase I, Prophase II and Telophase II
                      B   Metaphase I, Telophase I, Prophase II and Metaphase II
                      C   Anaphase I, Telophase I, Prophase II, Metaphase II and
                          Anaphase II
                      D   Prophase I, Telophase I, Prophase II, Metaphase II and
                          Telophase II

          1.1.8       The diagram below represents a process that occurs during protein
                      synthesis.

                                          W
                                                                       S

                                                                       T
                                                                       U

                                                                       V

                      Which ONE of the following is CORRECT?

                     A    S represents an anticodon
                     B    W represents mRNA
                     C    T represents tRNA
                     D    U represents an amino acid

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Life Sciences/P2                              6                            DBE/November 2021
                                             NSC

          1.1.9       Evidence of hominid cultural evolution can be found in the fossil
                      record.

                      This evidence would include the …

                      A   position of the attachment of the spine to the head.
                      B   length of the upper limbs compared to the length of the lower
                          limbs.
                      C   number of teeth present in the skull.                                   (18)
                      D   presence of stone tools.                             (9 x 2)

1.2       Give the correct biological term for each of the following descriptions.
          Write only the term next to the question numbers (1.2.1 to 1.2.6) in the
          ANSWER BOOK.

          1.2.1      A diagrammatic representation showing possible evolutionary
                     relationships between different species

          1.2.2      The type of bond found between amino acids

          1.2.3      The theory that describes evolution as consisting of long periods of
                     little/no change alternating with short periods of rapid change

          1.2.4      Similar structures that perform different functions in different
                     organisms

          1.2.5      The breeding of plants and animals by humans for desired
                     characteristics

          1.2.6      The type of dominance where both alleles of a gene are expressed
                     in the phenotype in the heterozygous condition            (6 x 1)            (6)

1.3       Indicate whether each of the statements in COLUMN I apply to A ONLY,
          B ONLY, BOTH A AND B or NONE of the items in COLUMN II. Write A only,
          B only, both A and B, or none next to the question number (1.3.1 to 1.3.3) in
          the ANSWER BOOK.

                       COLUMN I                                  COLUMN II
          1.3.1 Mechanisms of reproductive         A:   Species-specific courtship
                isolation                               behaviour
                                                   B:   Breeding at different times of the
                                                        year
          1.3.2 Fossils found in South Africa A:        Little Foot
                                              B:        Taung Child
          1.3.3 Proposed the 'law' of use and A:        Eldredge
                disuse'                       B:        Gould
                                                                                     (3 x 2)      (6)

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Life Sciences/P2                             7                           DBE/November 2021
                                            NSC

1.4       The diagram below represents part of a DNA molecule.

                                            W     X        Y         Z

                              Strand 1             Strand 2

          1.4.1      Identify the:

                     (a) Molecule X                                                            (1)

                     (b) Sugar at Y                                                            (1)

                     (c) Bond W                                                                (1)

          1.4.2      Give the collective name of parts X, Y and Z.                             (1)

          1.4.3      State the natural shape of the DNA molecule.                              (1)

          1.4.4      Name the process whereby DNA makes a copy of itself.                      (1)

          1.4.5      Name TWO places in an animal cell where DNA is located.                   (2)
                                                                                               (8)

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Life Sciences/P2                              8                     DBE/November 2021
                                             NSC

1.5       The diagram below represents a chromosome pair undergoing a process
          during meiosis.

                                         P

                         Q

                          R

          1.5.1      Name the:

                     (a) Organ in the human male where meiosis occurs                      (1)

                     (b) Process represented in the diagram                                (1)

          1.5.2      Label:

                     (a) Area P                                                            (1)

                     (b) Structure Q                                                       (1)

                     (c) Structure R                                                       (1)
                                                                                           (5)

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Life Sciences/P2                               9                        DBE/November 2021
                                              NSC

1.6       In humans, short fingers (F) and a widow's peak (H) are dominant over long
          fingers and continuous hairline. A man and a woman, both heterozygous for
          the two characteristics, plan on having a child.

          The table below shows the possible genotypes of the offspring.

                      Gametes           FH            Fh           fH           fh
                        FH             FFHH          FFHh        FfHH          FfHh
                        Fh             FFHh          FFhh        FfHh          Ffhh
                        fH             FfHH          FfHh        ffHH            Z
                        fh             FfHh          Ffhh        ffHh          ffhh

          1.6.1      State the genotype at Z.                                                  (1)

          1.6.2      Give the:

                     (a)   Genotype of the parents                                             (2)

                     (b)   Number of genotypes that could result in offspring with short
                           fingers and a continuous hairline                                   (1)

                     (c)   Allele for a continuous hairline                                    (1)

                     (d)   Phenotype of a child who is homozygous recessive for both
                           characteristics                                                     (2)
                                                                                               (7)

                                                                   TOTAL SECTION A:            50

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Life Sciences/P2                             10                        DBE/November 2021
                                            NSC

SECTION B

QUESTION 2

2.1       The diagram below represents two processes that occur during protein
          synthesis.

                            DNA         mRNA             PROTEIN
                                        A

                                    X             Y

         2.1.1       Where in the cell does EACH of the following processes occur?

                     (a)   X                                                                  (1)

                     (b)   Y                                                                  (1)

          2.1.2      State ONE difference between the types of nitrogenous bases
                     found in DNA and RNA.                                                    (2)

          2.1.3      Name and describe process X.                                             (6)
                                                                                              (10)

2.2      Describe how non-disjunction may lead to Down syndrome.                              (5)

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Life Sciences/P2                                    11                        DBE/November 2021
                                                   NSC

2.3      The diagram below represents the chromosomes from the human somatic cells
         of two individuals who are twins.

                               INDIVIDUAL 1                          INDIVIDUAL 2

             1        2          3      4     5     6       1     2      3    4        5        6

             7       8          9      10    11    12      7     8       9    10      11        12

            13       14         15      16    17    18     13    14     15    16      17        18

            19       20         21      22   23            19    20     21   22       23

         2.3.1           What are somatic cells?                                                        (1)

         2.3.2           Name the specific type of chromosomes numbered 1 to 22.                        (1)

         2.3.3           Each of the pairs shown is a homologous pair of chromosomes.

                         (a)        State the origin of each chromosome in a homologous pair
                                    during zygote formation.                                            (2)

                         (b)        List THREE characteristics that     chromosomes        in       a
                                    homologous pair have in common.                                     (3)

         2.3.4           Explain ONE observable reason why the two individuals are not
                         identical twins.                                                               (3)
                                                                                                        (10)

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Life Sciences/P2                                 12                        DBE/November 2021
                                                NSC

2.4       One type of deafness in humans is carried on a single allele. The diagram
          below shows the inheritance of deafness in a family.

                                   Paul        Lizzy     Mary      John

                                                  Bob     Ann

                            KEY:
                                   Hearing male           Hearing female

                                   Deaf male              Deaf female

         2.4.1       How many:
                     (a)   Generations are represented in this pedigree diagram                   (1)

                     (b)   Children of Paul and Lizzy are able to hear                            (1)

          2.4.2      Which phenotype is dominant?                                                 (1)

          2.4.3      Use the offspring of Bob and Ann to explain your answer to
                     QUESTION 2.4.2.                                                              (4)

          2.4.4      Use the letter 'A' to represent the dominant allele and the letter 'a'
                     for the recessive allele to give ALL the possible genotypes for a
                     hearing individual.                                                          (2)
                                                                                                  (9)

2.5       Use a genetic cross to show how gender in human offspring is determined by
          the sex chromosomes of the parents.                                                     (6)

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Life Sciences/P2                                  13                     DBE/November 2021
                                                 NSC

2.6      Read the extract below.

         Researchers have discovered that members of a particular family have high
         bone density that may be caused by a gene mutation. High bone density
         reduces the risk of bone fractures.

         Twenty members of the family had their bone density measured and DNA
         samples taken. Seven had high bone density. The high bone density occurred
         throughout their bodies but especially in the spine and hips.

         2.6.1       From the extract, identify TWO areas in the body where bone density
                     can mainly be measured.                                                    (2)

         2.6.2       Describe what a gene mutation is.                                          (2)

         2.6.3       Explain why it was necessary for the researchers to collect DNA
                     samples.                                                                   (2)

         2.6.4       State the effect of this mutation.                                         (1)

         2.6.5       Calculate the percentage of the family members who had normal
                     bone density. Show ALL your workings.                                      (3)
                                                                                                (10)
                                                                                                [50]

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Life Sciences/P2                               14                         DBE/November 2021
                                              NSC

QUESTION 3

3.1       Some horses have straight hair and others have curly hair. A scientist wanted
          to clone a straight-haired male horse to meet the demand for horses with
          straight hair.

          The scientist used the following procedure:

              The nucleus of a somatic cell was taken from a straight-haired male
               horse (horse S).
              An unfertilised ovum was removed from a curly-haired female horse
               (horse T).
              The nucleus from the somatic cell of horse S was placed into the ovum
               taken from horse T.
              This ovum was then placed into the uterus of a female surrogate horse
               (horse R).

          3.1.1      Explain why a somatic cell and NOT a sperm cell from horse S
                     would provide the nucleus for the procedure.                                (3)

          3.1.2      Before inserting the nucleus from the somatic cell of horse S, the
                     nucleus from the ovum of horse T was removed.

                     Explain the significance of this procedure.                                 (2)

          3.1.3      To which of the three horses (S, T or R) will the cloned offspring be
                     genetically identical?                                                      (1)

          3.1.4      State TWO benefits of cloning.                                              (2)
                                                                                                 (8)

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Life Sciences/P2                                                           15                          DBE/November 2021
                                                                          NSC

3.2       The present-day distribution of three closely related species of the dog family,
          the coyote, jackal and dingo, is shown on the world map below.

            Coyote

                                                                      Jackal
                                                                                     Dingo

          3.2.1                                   What type of evidence for evolution is represented here?                    (1)

          3.2.2                                   What is a biological species?                                               (3)

          3.2.3                                   Describe how these three species could have evolved from a
                                                  common ancestor.                                                            (7)
                                                                                                                              (11)
3.3       Some farmers add low doses of antibiotics to the feed for cattle. The use of
          antibiotics in cattle feed could result in the evolution of antibiotic-resistant
          bacteria.
          The graph below shows the effect of different doses of antibiotics on the
          number of harmful bacteria in the cattle.

                                                             Effect of different doses of antibiotics on the number
                                                                         of harmful bacteria in livestock

                     Number of harmful bacteria
                                                  1200
                                                  1000
                                                   800
                                                   600
                                                   400
                                                   200
                                                      0
                                                              2          4          6          8          10
                                                                      Antibiotic dose (mg)

          3.3.1                                   Use evidence from the graph to explain why higher doses of
                                                  antibiotics will benefit the farmer economically.                           (4)
          3.3.2                                   Explain how the use of antibiotics in animal feed may result in the
                                                  evolution of antibiotic resistant bacteria.                                 (6)
                                                                                                                              (10)

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Life Sciences/P2                               16                             DBE/November 2021
                                              NSC

3.4      Female gallflies lay eggs on the stems of plants. The eggs hatch to form
         larvae that secrete a substance into the plant tissue. The secretions cause the
         plant cells to grow and form ball-like structures, called galls, which are high in
         nutrients. Predatory birds feed on the larvae in the galls.
         The size of the galls produced actually depends on genetic variation in the
         gallfly.
         The diagram below shows the gallfly and a gall on a plant stem.

                                     The gallfly

                                                                     Gall on a
                                                                     stem

         Scientists wanted to investigate whether the size of the galls had an effect on
         the percentage of gallfly larvae killed by predatory birds.
         The table below shows the results of their investigation.

                      Gall size      Gallfly larvae killed by predatory birds
                       (mm)                              (%)
                         10                               1
                         15                               0
                         20                               1
                         25                               2
                         30                               10

         3.4.1       State the:

                     (a)    Independent variable                                                    (1)

                     (b)    Dependent variable                                                      (1)
          3.4.2       Give ONE advantage of the gall to the gallfly larvae.                         (1)

          3.4.3       State why the size of the galls produced is an example of
                      continuous variation.                                                         (1)

          3.4.4       Explain how the percentage of gallfly larvae killed by predatory
                      birds is influenced by the size of the gall.                                  (3)

          3.4.5       Draw a line graph to represent the information in the table.                  (6)
                                                                                                    (13)

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Life Sciences/P2                             17                         DBE/November 2021
                                            NSC

3.5      The diagram below represents the pelvic structure and the ventral view of the
         skulls of three organisms. The diagrams are drawn to scale.

                      A                       B                             C

                       X                      Y                         Z

         3.5.1       Write down the LETTER(S) of the diagram(s) that represent the:

                     (a)   Skulls of bipedal organisms                                      (2)

                     (b)   Pelvic structure of a quadrupedal organism                       (1)

         3.5.2       Give a reason for your answer to QUESTION 3.5.1(b).                    (2)

         3.5.3       Describe ONE other structural difference between a bipedal and a
                     quadrupedal organism.                                                  (3)
                                                                                            (8)
                                                                                            [50]

                                                                  TOTAL SECTION B:          100
                                                                     GRAND TOTAL:           150

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