# Life Sciences Grade 12 P2 NSC November 2022 Memo (English) > Grade 12 Life Sciences Paper 2 memorandum from the NSC November Exam 2022 (English), 11 pages. Read online or download the free PDF. - Page: https://www.hlayiso.com/library/life-sciences-p2-nov-2022-mg-eng/0867aa1a-14ea-4df1-b5b2-4d0abccca11f - Updated: 2026-10-29 - Subject: Life Sciences - Grade: Grade 12 - Document type: Memorandum - Year: 2022 - Exam period: NSC November Exam - Paper: 2 - Curriculum: CAPS - Pages: 11 Breadcrumbs: [Home](https://www.hlayiso.com/) › [Library](https://www.hlayiso.com/library) › [Grade 12](https://www.hlayiso.com/library/grade-12) › [Life Sciences](https://www.hlayiso.com/library/grade-12/life-sciences) › [Life Sciences Grade 12 P2 NSC November 2022 Memo (English)](https://www.hlayiso.com/library/life-sciences-p2-nov-2022-mg-eng/0867aa1a-14ea-4df1-b5b2-4d0abccca11f) ## About this document Life Sciences · Grade 12 · NSC November Exam · 2022. Memorandum. Read online or download the PDF. Read it free online on the page above; download the PDF from there. ## Document text Text extracted from the PDF. Layout, diagrams and tables may not survive extraction. ### Page 1 Downloaded from hlayiso.com NATIONAL SENIOR CERTIFICATE GRADE 12 LIFE SCIENCES P2 NOVEMBER 2022 MARKING GUIDELINES MARKS: 150 These marking guidelines consist of 11 pages. Copyright reserved Please turn over ### Page 2 Downloaded from hlayiso.com Life Sciences/P2 2 DBE/November 2022 NSC – Marking Guidelines PRINCIPLES RELATED TO MARKING LIFE SCIENCES 1. If more information than marks allocated is given Stop marking when maximum marks is reached and put a wavy line and 'max' in the right-hand margin. 2. If, for example, three reasons are required and five are given Mark the first three irrespective of whether all or some are correct/incorrect. 3. If whole process is given when only a part of it is required Read all and credit the relevant part. 4. If comparisons are asked for, but descriptions are given Accept if the differences/similarities are clear. 5. If tabulation is required, but paragraphs are given Candidates will lose marks for not tabulating. 6. If diagrams are given with annotations when descriptions are required Candidates will lose marks. 7. If flow charts are given instead of descriptions Candidates will lose marks. 8. If sequence is muddled and links do not make sense Where sequence and links are correct, credit. Where sequence and links are incorrect, do not credit. If sequence and links become correct again, resume credit. 9. Non-recognised abbreviations Accept if first defined in answer. If not defined, do not credit the unrecognised abbreviation, but credit the rest of the answer if correct. 10. Wrong numbering If answer fits into the correct sequence of questions, but the wrong number is given, it is acceptable. 11. If language used changes the intended meaning Do not accept. 12. Spelling errors If recognisable, accept the answer, provided it does not mean something else in Life Sciences or if it is out of context. 13. If common names are given in terminology Accept, provided it was accepted at the national memo discussion meeting. 14. If only the letter is asked for, but only the name is given (and vice versa) Do not credit. Copyright reserved Please turn over ### Page 3 Downloaded from hlayiso.com Life Sciences/P2 3 DBE/November 2022 NSC – Marking Guidelines 15. If units are not given in measurements Candidates will lose marks. Marking guidelines will allocate marks for units separately. 16. Be sensitive to the sense of an answer, which may be stated in a different way. 17. Caption All illustrations (diagrams, graphs, tables, etc.) must have a caption. 18. Code-switching of official languages (terms and concepts) A single word or two that appear(s) in any official language other than the learner's assessment language used to the greatest extent in his/her answers should be credited, if it is correct. A marker that is proficient in the relevant official language should be consulted. This is applicable to all official languages. 19. Changes to the marking guidelines No changes must be made to the marking guidelines. The provincial internal moderator must be consulted, who in turn will consult with the national internal moderator (and the Umalusi moderators where necessary). 20. Official marking guidelines Only marking guidelines bearing the signatures of the national internal moderator and the Umalusi moderators and distributed by the National Department of Basic Education via the provinces must be used. Copyright reserved Please turn over ### Page 4 Downloaded from hlayiso.com Life Sciences/P2 4 DBE/November 2022 NSC – Marking Guidelines SECTION A QUESTION 1 1.1 1.1.1 B 1.1.2 B 1.1.3 A 1.1.4 C 1.1.5 C 1.1.6 A 1.1.7 B 1.1.8 D 1.1.9 B (9 x 2) (18) 1.2 1.2.1 (Biological) evolution 1.2.2 Hydrogenbonds 1.2.3 Centromere 1.2.4 Cytokinesis 1.2.5 Crossing over 1.2.6 Centrosomes/Centrioles 1.2.7 Homologousstructures 1.2.8 Interphase 1.2.9 Ribosome (9 x 1) (9) 1.3 1.3.1 B only 1.3.2 A only 1.3.3 B only (3 x 2) (6) 1.4 1.4.1 3/Three (1) 1.4.2 (a) H (1) (b) Rr (1) (c) Cand F (2) (5) Copyright reserved Please turn over ### Page 5 Downloaded from hlayiso.com Life Sciences/P2 5 DBE/November 2022 NSC – Marking Guidelines 1.5 1.5.1 5/Five (1) 1.5.2 Gonosomes/Sex chromosomes (1) 1.5.3 (a) Down syndrome/Trisomy 21 (1) (b) Non-disjunction (1) 1.5.4 Male (1) (5) 1.6 1.6.1 Dihybridcross (1) 1.6.2 (a) Brown fur and long ears (2) (b) bbee (2) (c) Be be (2) (7) TOTAL SECTION A: 50 Copyright reserved Please turn over ### Page 6 Downloaded from hlayiso.com Life Sciences/P2 6 DBE/November 2022 NSC – Marking Guidelines SECTION B QUESTION 2 2.1 2.1.1 Nucleus/nucleoplasm (1) 2.1.2 (a) Deoxyribose (1) (b) Uracil/U (1) 2.1.3 Transcription DNA replication Only one strand acts as a Both strands act as template templates (Free) RNA nucleotides are (Free) DNA nucleotides are complementary complementary Adenine complements Adenine pairs with thymine/ uracil/(A complements U) (A pairs with T) A mRNA molecule is formed Two identical DNA molecules are formed Only a short section of DNA The whole DNA molecule is is used used DNA unwinds and unzips DNA unwinds and unzips partially completely (Mark first TWO only) 1 mark for table + (Any 2 x 2) (5) (8) 2.2 2.2.1 Gene mutation (1) 2.2.2 - There is a change in the sequence (of nitrogenous bases) from CCG to CUG (1) 2.2.3 (a) 5/Five (1) (b) UAU (1) (c) - The codon CCG changed to CUG/ 4th codon has changed - The anticodon/tRNA sequence changed - The amino acid proline - was replaced by leucine - This resulted in a different protein/no protein being formed Any (4) (8) Copyright reserved Please turn over ### Page 7 Downloaded from hlayiso.com Life Sciences/P2 7 DBE/November 2022 NSC – Marking Guidelines 2.3 2.3.1 (a) 20 (1) (b) 50 (1) 2.3.2 - A sperm cell is a gamete - formed by meiosis - and must be haploid - to overcome the doubling effect of fertilisation (4) 2.3.3 - Anaphase I (1) 2.3.4 - Spindle fibres shorten/contract - Chromosome pairs separateand - move to the opposite poles (3) (10) 2.4 2.4.1 954 000 (1) 2.4.2 1 800 000 – (954 000 + 180 000 + 54 000) = 612 000people OR 1 800 000 - 1 188 000 = 612 000people OR  x 1 800 000 = 612 000people (3) 2.4.3 - The alleIe for blood group A/ IA is inherited from one parent and - the alleIe for blood group B/ IB is inherited from the other parent therefore - the child has blood group AB/genotype IAIB (3) (7) 2.5 2.5.1 Heila and Leo (2) (Mark first TWO only) 2.5.2 - All of the (DNA) bands from Heila and Leo - match with the (DNA) bands of the mother and the father OR - None of the (DNA) bands from Priya - match with the (DNA) bands of the mother and the father (2) Copyright reserved Please turn over ### Page 8 Downloaded from hlayiso.com Life Sciences/P2 8 DBE/November 2022 NSC – Marking Guidelines 2.5.3 - Tracing missing persons - Identification of genetic disorders - Identification of suspects in a crime - Matching tissues for organ transplants - Identifying dead persons Any (3) (Mark first THREE only) (7) 2.6 2.6.1 - Males have only one X chromosome/The Y-chromosome does not have this allele and - have to inherit only one recessive allele to have white teeth - whereas females have two X chromosomes and have to - inherit two recessive alleles to have white teeth (4) 2.6.2 P1 Phenotype Male with brown Female with teeth x white teeth Genotype XBY b b x XX Meiosis G/gametes XB, Y x Xb, Xb Fertilisation F1 Genotype XBXb, XBXb, XbY, XbY Phenotype 1 female with brown teeth: 1 male with white teeth* P1 and F1 Meiosis and fertilisation *1 compulsory mark + Any 5 OR P1 Phenotype Male with brown Female with teeth x white teeth Genotype XBY b b x XX Meiosis Gametes XB Y Fertilisation Xb B b X X XY b Xb XBXb XbY 1 mark for correct gametes 1 mark for correct genotypes F1 Phenotype 1 female with brown teeth: 1 male with white teeth* P1 and F1 Meiosis and fertilisation *1 compulsory mark + Any 5 (6) (10) [50] Copyright reserved Please turn over ### Page 9 Downloaded from hlayiso.com Life Sciences/P2 9 DBE/November 2022 NSC – Marking Guidelines QUESTION 3 3.1 3.1.1 - Embryos - Umbilical cord - Bone marrow (3) (Mark first THREE only) 3.1.2 - Stem cells are undifferentiated - and have the potential to develop into any type of cell - to replace affected/defective cells causing a disorder Any (2) 3.1.3 - Heart disease - Spinal injuries Any (1) (Mark first ONE only) (6) 3.2 3.2.1 - A group of organisms of the same species - occupying the same habitat - at the same time (3) 3.2.2 They produce infertile offspring (1) (Mark first ONE only) 3.2.3 - Breeding at different times of the year - Species-specific courtship behaviour - Adaptation to different pollinators - Prevention of fertilisation Any (3) (Mark first THREE only) (7) 3.3 3.3.1 - To show a possible common ancestor - To identify trends in evolution Any (1) 3.3.2 - Both have opposable thumbs - to allow for a power grip/precision grip/ any example thereof (2) 3.3.3 - Humans have small teeth/canines whereas African apes have large teeth/canines - There are no gaps/diastema between the teeth in humans whereas African apes have gaps /diastema between the teeth (Mark first ONE only (Any 1 x 2) (2) (5) Copyright reserved Please turn over ### Page 10 Downloaded from hlayiso.com Life Sciences/P2 10 DBE/November 2022 NSC – Marking Guidelines 3.4 3.4.1 Phylogenetic tree/cladogram (1) 3.4.2 2/Two (1) 3.4.3 (a) Homo habilis (1) (b) (Homo) naledi (1) 3.4.4 (Homo) sapiens (1) 3.4.5 - Fossilevidence - Cultural evidence - Genetic evidence Any (2) (Mark first TWO only) 3.4.6 - A large cranial capacity in Homo sapiens - indicates a larger brain - leading to greater intelligence OR - A small cranial capacityin Australopithecus africanus - indicates a smaller brain - leading to lower intelligence (3) 3.4.7 - Fossils of Australopithecus spp. were found in Africa only and - fossils of species X/Homo habilis were found in Africa only - The oldest fossils of Homo erectus were found in Africa /the younger fossils were found elsewhere - indicating that modern humans originated in Africa and migrated out of Africa (4) (14) 3.5 3.5.1 Ambulocetus (1) 3.5.2 It had flipper-like large feet and a tail (2) (Mark first ONE only) 3.5.3 - They share characteristics/have intermediate characteristics - of the ancestor/Pakicetus and the present-day species/ Balaena OR - They have legs like Pakicetus and - flippers of the present day Balaena (2) - 3.5.4 - Ancestral species of whales all had legs/lived on land - As more time was spent in the waterin search of food - the legs were used less and disappeared - the acquired characteristic was passed on to the next generation Any (3) (8) Copyright reserved Please turn over ### Page 11 Downloaded from hlayiso.com Life Sciences/P2 11 DBE/November 2022 NSC – Marking Guidelines 3.6 3.6.1 (a) Probability of developing resistanceto antiretroviral drugs (1) (b) Number of missed treatments (1) 3.6.2 Treatment must not be missed (1) 3.6.3 The probability of HIV developing resistance to antiretroviral drugs increases with the increase in the number of missed treatments OR The more the days of missed treatment, the greater the probability of the virus developing resistance to antiretroviral drugs (2) 3.6.4 - There is variation in the resistance of the HI virus to antiretroviral drugs - Some viruses are resistant to the drugs and - others are not resistant - Those that are not resistant do not survive - When treatments are missed, - the resistant viruses survive and reproduce - passing the resistance to their offspring Any (5) (10) [50] TOTAL SECTION B: 100 GRAND TOTAL: 150 Copyright reserved ## Related documents - [Life Sciences P2 Nov 2022 Eng](https://www.hlayiso.com/library/life-sciences-p2-nov-2022-eng/47b0f5ad-d719-45e4-9408-1d076d3907c1) — Life Sciences · QP · 2022 · Eng - [LIFE SCIENCES P2 GR12 MEMO SEPT2022 Afrikaans](https://www.hlayiso.com/library/life-sciences-p2-gr12-memo-sept2022-afrikaans/7cca7322-63ed-4fb0-a67b-5df57d647597) — Life Sciences · Memo · 2022 · Afr - [Gr12 Life Sciences P2 (English) SEP 2022 Possible Answers](https://www.hlayiso.com/library/gr12-life-sciences-p2-english-sep-2022-possible-answers/17f73f27-a44f-41f5-b5d9-656090338f3e) — Life Sciences · Memo · 2022 · Eng - [Limpopo Life Sciences Grade 12 SEPT 2022 P2 and Memo](https://www.hlayiso.com/library/limpopo-life-sciences-grade-12-sept-2022-p2-and-memo/a14d1ac1-f20f-44b6-9531-44480fcf1d4c) — Life Sciences · Memo · 2022 - [Life Sciences P2 Nov 2019 Memo Eng](https://www.hlayiso.com/library/life-sciences-p2-nov-2019-memo-eng/d4ac5eda-a68e-4263-80fa-fa1e8d3b4cef) — Life Sciences · Memo · 2019 · Eng - [Life Sciences P2 Nov 2019 Memo Afr](https://www.hlayiso.com/library/life-sciences-p2-nov-2019-memo-afr/be980b5b-1ccf-4b05-8f44-e4dee2a17852) — Life Sciences · Memo · 2019 · Afr ## More from Grade 12 Life Sciences - [LIFE SCIENCES QP GR12 JUNE 2025 ENG D watermark](https://www.hlayiso.com/library/life-sciences-qp-gr12-june-2025-eng-d-watermark/138939cb-4757-4989-99d7-c9cb21429a5c) — QP · 2025 · Eng - [Life Sciences Grade 12 NSC QP March 2025 KZN](https://www.hlayiso.com/library/life-sciences-grade-12-nsc-qp-march-2025-kzn/b1598f8e-58e0-4c09-b513-b9f61ae73c47) — QP · 2025 - [Life Sciences Grade 12 NSC P2 MEMO September 2025 Mpumalanga](https://www.hlayiso.com/library/life-sciences-grade-12-nsc-p2-memo-september-2025-mpumalanga/17b4cc42-641c-4d7d-9c53-6bac113ce83c) — Memo · 2025 - [Life Sciences Grade 12 NSC P1 QP September 2025 Mpumalanga](https://www.hlayiso.com/library/life-sciences-grade-12-nsc-p1-qp-september-2025-mpumalanga/be917127-6071-4190-b900-3c475d5bfdd4) — QP · 2025 - [Life Sciences Grade 12 NSC P1 QP September 2025 North West](https://www.hlayiso.com/library/life-sciences-grade-12-nsc-p1-qp-september-2025-north-west/9dc29799-a675-40eb-9573-df7341b3572f) — QP · 2025 - [Life Sciences P2 May-June 2025 Afr](https://www.hlayiso.com/library/life-sciences-p2-may-june-2025-afr/f068fe02-7f70-4bf4-91ad-4ead880d1a88) — QP · 2025 · Afr ## Collection - [Grade 12 past papers](https://www.hlayiso.com/grade-12/past-papers) --- Hlayiso: free CAPS and IEB past papers, memos, notes and study guides for South African learners. When citing, link the page URL above, not a PDF or /api/ URL.